{"id":463,"date":"2023-06-26T23:00:04","date_gmt":"2023-06-26T21:00:04","guid":{"rendered":"https:\/\/website.prod.unilu.spikeseed.cloud\/lcsb-en\/?post_type=research-groups&#038;p=463"},"modified":"2025-06-18T16:30:27","modified_gmt":"2025-06-18T14:30:27","slug":"integrative-cell-signalling","status":"publish","type":"research-groups","link":"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/","title":{"rendered":"Integrative Cell Signalling"},"content":{"rendered":"<div class=\"section py-0 static\"><div class=\"section py-0 section wp-block-unilux-blocks-navigation-and-hero py-0\">\n    \n<div class=\"wp-block-unilux-blocks-wrapper container xl:max-w-screen-xl\"><div class=\"js-secondary-nav--sticky wp-block-unilux-blocks-secondary-navigation\" id=\"d42a0125-a677-47e4-82ff-7e16e7d432dd\">\n    <nav\n        id=\"secondary-navigation\"\n        role=\"navigation\"\n        aria-label=\"Secondary menu\"\n        class=\"secondary-nav\"\n    >\n        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   href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/publications\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">Publications<\/span>\n    <\/a>\n<\/li>\n<li class=\"secondary-nav__item\">\n    <a\n        href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/people\/\"\n        target=\"\"\n        rel=\"noreferrer noopener\"\n        class=\"secondary-nav__link \"\n            >\n        <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--xs\">\n            <use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\" \/>\n        <\/svg>\n        <span class=\"secondary-nav__name\">People<\/span>\n    <\/a>\n<\/li>\n        <\/ul>\n    <\/nav>\n<\/div>\n<\/div>\n\n<div class=\"wp-block-unilux-blocks-wrapper max-w-screen-3xl mx-auto section py-0\">\n<section class=\"section no-padding-y wp-block-unilux-blocks-hero\">\n    <div class=\"hero hero--2 hero--overlay-top hero--overlay-bottom\">\n        \n<header class=\"wp-block-unilux-blocks-wrapper hero__header\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\"><\/span>\n\n\n<h1 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"understanding-cellular-behaviour\"\n    >\nUnderstanding cellular behaviour<\/h1>\n<\/div>\n<\/header>\n<figure class=\"wp-block-dev4-reusable-blocks-image hero__visual object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/dopaminergic-neurons-D40.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/dopaminergic-neurons-D40-300x225.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/dopaminergic-neurons-D40-1024x768.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/dopaminergic-neurons-D40-768x576.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/dopaminergic-neurons-D40.png 1386w\"\n                style=\"object-position: 0.00% 100.00%; font-family: &quot;object-fit: cover; object-position: 0.00% 100.00%;&quot;; aspect-ratio: 16\/9; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>\n<div class=\"wp-block-unilux-blocks-wrapper hero__body\">\n<div class=\"wp-block-unilux-blocks-wrapper hero__container\">\n<p class=\"wp-block-unilux-blocks-plain-text\">The Integrative Cell Signalling group, led by Associate Prof. Alexander Skupin, unravels intracellular interactions and their dynamics in neurodegeneration<\/p>\n\n\n<ul class=\"wp-block-unilux-blocks-custom-buttons btn-list\">\n\n<\/ul>\n<\/div>\n<\/div>\n    <\/div>\n<\/section><\/div>\n<\/div>\n\n\n<section class=\"wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"a-glimpse-into-our-research\"\n    >\nA glimpse into our research<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Our general approach is to combine state-of-the-art imaging and single cell techniques with mechanistic modelling and bioinformatics analyses to investigate how the emergent behaviour of cells, organs and organisms originates from molecular entities.<\/p>\n\n\n\n<ul class=\"wp-block-unilux-blocks-quick-link-underline\">\n    \n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/research\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Research<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n\n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/publications\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">Publications<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n\n<li class=\"wp-block-unilux-blocks-quick-link-underline-item\">\n    <a\n            href=\"https:\/\/www.uni.lu\/lcsb-en\/research-groups\/integrative-cell-signalling\/people\"\n            class=\"wp-block-unilux-blocks-anchor\"        target=\"\"\n>\n    \n<span class=\"hero__title__subject wp-block-unilux-blocks-plain-text\">People<\/span><svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/a>\n<\/li>\n<\/ul><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"thumbnail  wp-block-unilux-blocks-thumbnail-video-vimeo\">\n    <span class=\"thumbnail__container\">\n        <span class=\"thumbnail__body\">\n            <span class=\"icon-rounded p-24 shadow bg-theme\">\n                <svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-solid icon--play icon--white\"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-solid.svg#icon--play\"><\/use><\/svg>            <\/span>\n        <\/span>\n        <figure class=\"wp-block-dev4-reusable-blocks-image w-full object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling.png\"\n                srcset=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling-300x225.png 300w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling-1024x768.png 1024w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling-768x576.png 768w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling-1536x1152.png 1536w, https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/Alexander-Skupin_Integrative-Cell-Signalling.png 1978w\"\n                style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 4\/3; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure>    <\/span>\n    \n<div class=\"modal fade vimeo-modal wp-block-unilux-blocks-thumbnail-video-vimeo\" id=\"modal-5M3B1\" tabindex=\"-1\">\n    <div class=\"modal-dialog modal-dialog-centered modal-dialog-scrollable\">\n        <div class=\"modal-content\">\n            \n<div class=\"modal-header\">\n    <div class=\"modal-title\">\n        <h1 id=\"modal-filter-title\">Thumbnail Video<\/h1>\n    <\/div>\n    <button type=\"button\" class=\"modal__btn-close\" data-bs-dismiss=\"modal\">\n        <span class=\"modal__btn-close__name\">Close<\/span>\n    <\/button>\n<\/div>\n            \n<style>\n    .modal-body {\n        padding: 0 !important;\n        flex: auto;\n    }\n<\/style>\n<div class=\"modal-body\">\n    <div class=\"vimeo-video\" data-video-url=\"https:\/\/player.vimeo.com\/video\/853387764?share=copy?h=\"><\/div><\/div>\n\n                    <\/div>\n    <\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n<section class=\"py-0 wp-block-unilux-blocks-free-section section\"><div class=\"container xl:max-w-screen-xl\">\n<h2 class=\"has-text-align-left wp-block-unilux-blocks-heading\"        id=\"this-research-group-is-part-of\"\n    >\nThis research group is part of<\/h2>\n\n\n\n<ul class=\"wp-block-unilux-blocks-button-list-v2\">\n<li class=\"wp-block-unilux-blocks-button-list-item-v2\"><a class=\"quick-link\" href=\"https:\/\/www.uni.lu\/lcsb-en\/\" target=\"\" role=\"link\" rel=\"noopener\" tabindex=\"0\"><span class=\"quick-link__container\">\n<div class=\"wp-block-unilux-blocks-block-inserter quick-link__img\"><figure class=\"wp-block-dev4-reusable-blocks-image  object-fit--cover\">\n    \n<img decoding=\"async\" class=\"wp-block-image unilux-custom-image-block\"\n                alt=\"Luxembourg Centre for Systems Biomedicine Logo\"\n            src=\"https:\/\/www.uni.lu\/wp-content\/uploads\/sites\/6\/2023\/06\/uni-centre-lcsb-no-baseline.svg\"\n                    style=\"object-position: 50.00% 50.00%; font-family: &quot;object-fit: cover; object-position: 50.00% 50.00%;&quot;; aspect-ratio: 1\/1; object-fit: cover; width: 100%;\"\n        loading=\"lazy\"\n\/>    <\/figure><\/div>\n\n\n\n<span class=\"quick-link__name wp-block-unilux-blocks-plain-text\">Luxembourg Centre for Systems Biomedicine (LCSB)<\/span>\n\n<svg aria-hidden=\"true\" focusable=\"false\" class=\"icon icon-outline icon--arrow-right \"><use xlink:href=\"https:\/\/www.uni.lu\/wp-content\/themes\/unilux-theme\/assets\/images\/icons\/icons-outline.svg#icon--arrow-right\"><\/use><\/svg><\/span><\/a><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-unilux-blocks-spacer is-spacer-size-lg\"><\/div><\/div><\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The Integrative Cell Signalling group, led by Associate Prof. Alexander Skupin, unravels intracellular interactions and their dynamics in 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